I would say yes. It sounds like a mismatch.
It sometimes happens that love/friendship is not enough. That some differencies are simply incompatible, however much you try, however much you grieve over it, or wish it different.
That is when you have to split up, however painful a thing that always is.
Let go with love, learn, and go search again.
I never said it was easy. Just nessecary.
The very best of luck on your way, a wishing you the happiness you seek.